Neurofuse Review: Can You Optimize Your Neurons?

by Ming C

Created by Harvard roommates, Neurofuse’s (click for best price) proprietary blend is a combination of 13 ingredients that have been clinically studied for their abilities to improve memory, focus, and mental performance. Many of the ingredients on the list have some effect on the neurotransmitter acetylcholine, a chemical responsible for a number of cognitive functions.

We put Neurofuse to the test. Read below to see what each of our four testers thought about this broad-spectrium nootropic stack in our full Neurofuse review.

Neurofuse Ingredients

Neurofuse Ingredients

The Ingredients

Neurofuse comes in capsule form. There are 30 two-capsule servings per bottle.

  • Vitamin D3, 667iu
    • Vitamin D3 is a fat-soluble vitamin many Westerners, especially adults, do not get enough of, making it one of our most common vitamin deficiencies. Vitamin D deficiency has been linked to cardiovascular disease, mood disorders, and impaired cognition. This isn’t a massive amount of vitamin D by any means, but it’s a fairly common inclusion in many nootropic stacks and may aid the absorption of other ingredients in Neurofuse.
  • Vitamin B6 (Pyridoxine), 3.3mg
    • Vitamin B6 is a water-soluble essential vitamin involved in the production of neurotransmitters. Studies show that when taken in conjunction with Magnesium, B6 improved school attention in children diagnosed with ADHD. Vitamin B6 may also increase the vividness of dreams and our ability to recall them.
  • Vitamin B12 (Cyanocobalamin), 33.3mcg
    • Vitamin B12 is a water-soluble essential vitamin directly related to brain health, including memory and actual brain mass. A number of studies have noted positive associations between vitamin B12 intake and memory tests.
  • Neurofuse Blend – 903mg
    • There are no listed amounts for each individual component of the proprietary blend, but the ingredients are below.Neurofuse Supplement Review
  • Rhodiola Rosea (3% Rosavins, 2% Salidrosides)
    • Rhodiola Rosea is a herb long used in holistic medicine as an anti-fatigue agent. It’s also linked to an increase in the brain’s ability to handle and process stress. This is a fairly common ingredient in many nootropics, and several of our testers find it effective for them. It’s also been linked to very few, if any, negative side effects in clinical and research studies.
  • Caffeine Anhydrous
    • Caffeine is a stimulant acting on the central nervous system. One of the better-researched mental and physical performance enhancers, caffeine is proven to have acute effects on cognitive function and mood when used in conjunction with L-Theanine. This is a combo naturally present in green tea, which could account for that beverage’s calming effects.
  • L-Theanine
  • Bacopa Monnieri P.E. 20%
    • Bacopa Monnieri is an adaptogenic herb used in Ayurveda as an antidepressant and a cognitive booster. While performing stressful cognitive tests, users taking Bacopa Monnieri experienced reduced stress and lowered cortisol (a stress hormone) levels.
  • DMAE Bitartrate
    • DMAE Bitrate, or Deanol,  is a chemical that’s been used to treat ADHD, improve memory, and boost cognitive function. Deanol is essential to the production of choline, one of the building blocks of the neurotransmitter acetylcholine, which is vital for a number of nervous system activities, including signaling the heart to keep beating.
  • Phosphatidylserine 20%
    • Phosphatidylserine is a phospholipid required to maintain healthy nerve cell membranes. It supports cognitive function and the ability to learn and recall new information.
  • Alpha Lipoic Acid
    • Alpha Lipoic Acid is an antioxidant and anti-inflammatory chemical that has been used to treat memory loss and chronic fatigue syndrome.
  • Choline-Bitartrate
    • Choline-Bitartrate, a vitamin-like chemical, is thought to help enhance the levels of acetylcholine in the brain and body, one of the neurotransmitters involved in learning, and other cognitive processes. Some broad spectrum nootropic stacks include compounds involved in choline production without actually pairing them with a choline source; Neurofuse seems to have avoided that mistake.
  • Vinpocetine
    • Vinpocetine is a chemical derived from the periwinkle plant, possibly linked to increased cerebral blood flow.
  • Huperzine A
    • Huperzine A is a compound derived from Chinese club moss that has been used to improve cognitive performance in patients with Alzheimer’s.
  • Other Ingredients: Brown Rice Flour, Magnesium Stearate, Titanium Dioxide, Gelatin

Usage Guidelines

For mental performance: Start with 1-2 capsules per day with food. Work up to 3-4 capsules depending on desired effect and tolerance.

Note: We had BrainWiz testers take between 1 and 4 capsules per day to test a broad range of dosages.

What Our Testers Say

“This supplement was great for me. I took this an hour before heading into the gym  in lieu of my caffeine-containing pre-workout drink, and it was very effective. I had great workouts, and both the energy and sharpened focused lasted well after my workout was over. I started with two capsules and worked my way up to four. That may be a pretty high dosage for simply being productive at work, but I noticed an effect on my workouts, definitely.”

“Neurofuse gave me a jolt of energy. I started with one pill, and although I felt focused and sharp, I also experienced some slight, very slight, jitteriness. The next time I took it, I didn’t experience the jitters, though I stayed at a pretty low dosage (never more than two capsules, most often just one was enough). I would love to see this product offered without the caffeine, since I did feel like it increased my ability to focus and get through an enormous opposition brief under a tight deadline. I will take Neurofuse again, but like I said, probably one capsule at a time.”

“I started out taking 1 capsule (I also drink coffee in the morning). It gave me a definite sharpness well into the afternoon during the workday. I worked up to three capsules. I didn’t experience the big energy wave like some of the other BrainWiz testers, but I felt sharp and like I was able to handle stress just a little bit better than normal. This was one of the first nootropic stacks I ever tested, and I keep coming back to it at least once a month.”

“I started with two capsules and worked my way up to four. I felt focused and energized, for the first four days, but they the effects seemed to diminish a little bit over time. I took 1 day off, and then went back to three then four pills with great results.”

4.7 / 5 Score
  • Our top rated
  • Easy to time
  • Fought fatigue
  • Boosted energy
  • Boosted focus
  • Cons
  • Best cycled
  • Summary
    Neurofuse is one of the top-rated, broad-spectrum (i.e. a variety of ingredients, some synergistic, some good on their own) nootropics we've tried. We've found it consistent for lasting energy and focus, though we recommend people start with just one capsule to assess tolerance, as Neurofuse contains caffeine.
    Beginner Friendly

    BrainWiz Tips

    • Neurofuse contains caffeine, and although the amount is not listed, it is enough to cause jitteriness in people with caffeine sensitivity, if taken alongside your morning coffee. Do as the manufacturer says and start slowly.
    • In our review of Neurofuse, our testers preferred taking the nootropic stack in the morning or just after lunch to help fight the afternoon crash.
    • Except for the occasional jitteriness, our testers experienced no negative side effects from this supplement. But as with any supplement or nutritional regimen, you should talk to your doctor or medical professional before use.
    • Take just before eating to take advantage of an active digestive system and promote absorption.

    Neurofuse Summary

    Neurofuse is a broad-spectrium nootropic stack featuring a number of powerful, popular ingredients, including caffeine, in a convenient delivery system. It turned out to be a favorite among our testers, who all felt a cognitive boost.

    In addition to a mental boost, some of our testers feel increased physical energy and stamina; at least one of our testers found it most effective to take pre-workout. Though its perceived effects seemed to diminish very slightly over time, taking a break from the supplement for a day or two seems to be enough time for Neurofuse’s effectiveness to return.

    DISCLAIMER: We are not doctors. The opinions on this website are not to be taken as medical advice. None of these opinions have been reviewed by the FDA. Consult your doctor before taking any supplements. We receive free products to review and participate in affiliate programs, where we are compensated for items purchased through links from our site (at no cost to the buyer). See our disclosure page for our list of comped products and affiliate programs. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to


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