CILTEP and Smart Caffeine: Is This Natural Stacks Combo Worth It?

by Ming C

Nootropic and performance supplement company Natural Stacks produces a range of brain-enhancing products, from beginner-friendly nootropic blends to the innovative BioCreatine and rest-promoting MagTech. Two of their most famous supplements, though, are CILTEP and Smart Caffeine, and the company encourages users to try both as a focus and memory-boosting stack.

Smart Caffeine and CILTEP

Two of Natural Stack’s most famous supplements are CILTEP and Smart Caffeine, which the company encourages users to try both as a focus and memory-boosting stack. We put this stack to the test .

We’ve had positive experiences with MagTech (our favorite brain magnesium supplement), BioCreatine, and Smart Caffeine, though our testers had very mixed reviews on CILTEP. Developed by a popular biohacking forum contributor and subsequently produced by Natural Stacks, the theory behind CILTEP is that its ingredients, when taken in conjunction, boost Long Term Potentiation (LTP), basically a consistent strengthening of synapses in the brain. Read our CILTEP review here.

While one of our testers reported less brain fog while on CILTEP, the science behind the stack and whether or not the ingredients can make it past the digestive system is inconclusive. Overall, it’s a stack we don’t recommend for beginners, and the mechanisms and theory are definitely more suited toward the experienced biohacker who’s interested in learning about high-level synapse mechanisms. (And whether or not it truly works is still up in the air.)

When stacking CILTEP and Smart Caffeine, we only (reliably) experienced the effects of Smart Caffeine, which is basically a smoother, no-jitters caffeine boost complimented by the supplement’s l-theanine content. (Read our Smart Caffeine review here.)

We recommend anyone be careful when taking caffeine-containing supplements, starting off slow to assess personal tolerance. As far as stacking Smart Caffeine with CILTEP, we felt no difference when compared to taking Smart Caffeine on its own.

DISCLAIMER: We are not doctors. The opinions on this website are not to be taken as medical advice. None of these opinions have been reviewed by the FDA. Consult your doctor before taking any supplements. We receive free products to review and participate in affiliate programs, where we are compensated for items purchased through links from our site (at no cost to the buyer). See our disclosure page for our list of comped products and affiliate programs. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to

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